Asst. Prof. Dr.
Ahmet Tülek
Education
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D
GEBZE TEKNİK ÜNİVERSİTESİ
2016 - 2020
DoctorateFEN BİLİMLERİ ENSTİTÜSÜ/MOLEKÜLER BİYOLOJİ VE GENETİK (DR)/
Tez Adı: Characterization and redesign of a new laccase for industrial biotechnological applications
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M
ANKARA ÜNİVERSİTESİ
2008 - 2010
MasterFEN BİLİMLERİ ENSTİTÜSÜ/BİYOLOJİ (YL) (TEZSİZ)/
Tez Adı:
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M
GEBZE YÜKSEK TEKNOLOJİ ENSTİTÜSÜ
2010 - 2014
MasterMÜHENDİSLİK VE FEN BİLİMLERİ ENSTİTÜSÜ/MOLEKÜLER BİYOLOJİ VE GENETİK (YL) (TEZLİ)/
Tez Adı: ATP-bağımlı ftsH geninin Geobacillus kaustophilus'dan klonlanması ve ekspresyonu
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B
ANKARA ÜNİVERSİTESİ
2005 - 2008
Bachelor DegreeFEN FAKÜLTESİ/BİYOLOJİ BÖLÜMÜ/BİYOLOJİ PR./
Tez Adı:
22222
| Year: | Article Title | Scope | Author(s): | Journal Name: | Volume: | Issue: | Link: |
|---|---|---|---|---|---|---|---|
| 2022 | Biochemical characterization and detection of antitumor activity of l-asparaginase from thermophilic Geobacillus kaustophilus DSM 7263T | International | ÖZDEMİR FATMA İNCİ, ORHAN MÜGE DİDEM, ATASAVUM ZEYNEP TANSU, TÜLEK AHMET | Protein Expression and Purification | 199 | 106146 | http://dx.doi.org/10.1016/j.pep.2022.106146 |
| 2021 | Highly-stable Madurella mycetomatis laccase immobilized in silica-coated ZIF-8 nanocomposites for environmentally friendly cotton bleaching process | International | TÜLEK AHMET, YILDIRIM DENİZ, AYDIN DERYA, BİNAY BARIŞ | Colloids and surfaces B: Biointerfaces | 202 | 8 | http://dx.doi.org/10.1016/j.colsurfb.2021.111672 |
| 2022 | A new highly enantioselective stable epoxide hydrolase from Hypsibius dujardini: Expression in Pichia pastoris and immobilization in ZIF-8 for asymmetric hydrolysis of racemic styrene oxide | International | ONUR HAKAN, TÜLEK AHMET, YILDIRIM DENİZ, ASLAN ELİF SİBEL, BİNAY BARIŞ | Biochemical Engineering Journal | 189 | 108726 | http://dx.doi.org/10.1016/j.bej.2022.108726 |
| 2021 | Investigation of Diagnostic Proteins by 2D Electrophoresis in Major Depression Model Induced by Forced Swim Test in Rats | International | DUMAN TUĞÇE, AKYÜZ ENES, BULUT HURİ, KOÇYİĞİT ABDÜRRAHİM, TÜLEK AHMET, KARATAŞ ERSİN, KIRPINAR İSMET | Protein & Peptide Letters | 28 | 2 | http://dx.doi.org/10.2174/0929866527999200729183729 |
| 2024 | Fingermark development on living and dead subjects: analysis of thermal paper transfers with different methods | International | GÜLEKÇİ YAKUP, TÜLEK AHMET, ŞENER HARUN, KÜÇÜKER HÜDAVERDİ | Australian Journal of Forensic Sciences | 56 | 1 | http://dx.doi.org/10.1080/00450618.2022.2117412 |
| 2023 | Sustainable production of formic acid from CO2 by a novel immobilized mutant formate dehydrogenase | International | TÜLEK AHMET, GÜNAY ELİF, SERVİLİ BURAK, EŞSİZ ŞEBNEM, BİNAY BARIŞ, YILDIRIM DENİZ | Separation and Purification Technology | 309 | 123090 | http://dx.doi.org/10.1016/j.seppur.2022.123090 |
| 2020 | Cloning, Expression and Characterization of Membrane Bound FtsH Protease of Geobacillus kaustophilus | International | TÜLEK AHMET, ÖZDEMİR FATMA İNCİ, RAMADHAN SALİM SAİM | Applied Biochemistry and Microbiology | 56 | http://dx.doi.org/10.1134/s0003683820060186 | |
| 2021 | From Secretion in Pichia pastoris to Application in Apple Juice Processing: Exo-Polygalacturonase from Sporothrix schenckii 1099-18 | International | KARATAŞ ERSİN, TÜLEK AHMET, ÇAKAR MEHMET MERVAN, TAMTÜRK FARUK, AKTAŞ FATİH, BİNAY BARIŞ | Protein & Peptide Letters | 28 | 7 | http://dx.doi.org/10.2174/1871530321666210106110400 |
| 2020 | Optimisation of the Production and Bleaching Process for a New Laccase from Madurella mycetomatis, Expressed in Pichia pastoris: from Secretion to Yielding Prominent | International | TÜLEK AHMET, KARATAŞ ERSİN, ÇAKAR MEHMET MERVAN, AYDIN DERYA, YILMAZCAN ÖZLEM, BİNAY BARIŞ | Molecular Biotechnology | 63 | http://dx.doi.org/10.1007/s12033-020-00281-9 | |
| 2023 | Immobilization of recombinant l-asparaginase from Geobacillus kaustophilus on magnetic MWCNT-nickel composites | International | ÖZDEMİR FATMA İNCİ, KARAASLAN BURCU, TÜLEK AHMET, YÜCEBİLGİÇ GÜZİDE, YILDIRIM DENİZ | Process Biochemistry | 127 | 2023 | http://dx.doi.org/10.1016/j.procbio.2023.01.021 |
| 2021 | Identification and Heterologous Production of a Lipase from Geobacillus kaustophilus DSM 7263T and Tailoring Its N-Terminal by a His-Tag Epitope | International | ÖZDEMİR FATMA İNCİ, TÜLEK AHMET, ERDOĞAN DAVUT | The Protein Journal | 40 | 2 | http://dx.doi.org/10.1007/s10930-021-09987-4 |
| 2021 | Immobilization of Sporothrix schenckii 1099-18 exo-polygalacturonase in magnetic mesoporous silica yolk-shell spheres: Highly reusable biocatalysts for apple juice clarification | International | KARATAŞ ERSİN, TÜLEK AHMET, TAMTÜRK FARUK, YILDIRIM DENİZ, BİNAY BARIŞ | Food Bioscience | 43 | 1 | http://dx.doi.org/10.1016/j.fbio.2021.101324 |
| 2023 | Investigation of the Siderophore Production and Associated Heavy Metal Accumulation Potential of Brevibacillus laterosporus 301/İK3-2 | International | ÖZDEMİR FATMA İNCİ, AYDIN BAHADIR, TÜLEK AHMET | Hacettepe Journal of Biology and Chemistry | 51 | 3 | http://dx.doi.org/10.15671/hjbc.1256836 |
| 2023 | Covalent immobilization of recombinant L-asparaginase from Geobacillus kaustophilus on ReliZyme supports for mitigation of acrylamide | International | ÖZDEMİR FATMA İNCİ, KARAASLAN BURCU, TÜLEK AHMET, YILDIRIM DENİZ | Biocatalysis and Biotransformation | http://dx.doi.org/10.1080/10242422.2023.2257351 | ||
| 2023 | Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy | International | VERİMLİ NİHAN, GORALI SELEN İREM, ABİŞOĞLU BEYZA, ALTAN CEM LEVENT, SUCU BİLGESU ONUR, KARATAŞ ERSİN, TÜLEK AHMET, BAYRAKTAROĞLU ÇİĞDEM, BEKER MUSTAFA ÇAĞLAR, ERDEM SULTAN SİBEL | Journal of Photochemistry and Photobiology B: Biology | 248 | 112797 | http://dx.doi.org/10.1016/j.jphotobiol.2023.112797 |
| 2023 | Evaluating Enterococcus faecium9 N‐2 as a probiotic candidate from traditional village white cheese | International | DİKBAŞ NESLİHAN, ORMAN YUSUF CAN, ALIM ŞEYMA, UÇAR SEVDA, TÜLEK AHMET | Food Science & Nutrition | http://dx.doi.org/10.1002/fsn3.3878 | ||
| 2024 | Evaluation of multi-walled carbon nanotubes bearing aldehyde groups of different lengths for the immobilization of Geobacillus kaustophilus l-asparaginase | International | ÖZDEMİR FATMA İNCİ, TÜLEK AHMET, KARAASLAN BURCU, YILDIRIM DENİZ | Molecular Catalysis | 555 | 113903 | http://dx.doi.org/10.1016/j.mcat.2024.113903 |
| 2024 | Optimization of crystal violet technique for enhanced fingerprint detection on various surfaces | International | GÜLEKÇİ YAKUP,TÜLEK AHMET | Journal of Forensic Sciences | http://dx.doi.org/10.1111/1556-4029.15534 |
22222
| Year: | Paper Title | Scope: | Author(s): | Event Name: | Link: |
|---|---|---|---|---|---|
| 2024 | Osmolyte-Mediated Enhancement of Geobacillus Kaustophilus L-Asparaginase Activity: Performance Improvement and Acrylamide Mitigation | International | ÖZDEMİR FATMA İNCİ,DEMİRTAŞ ÖZGE,ŞÜKÜR GÖZDE,TÜLEK AHMET,YILDIRIM DENİZ | V. International Enzyme & Bioprocess Days | https://ebdays.org/ |
| 2024 | Enhancing Substrate Selectivity and Activity of G. kaustophilus Lipase: A Bioinformatics and Structural Approach | International | POYRAZ YAĞMUR,TÜLEK AHMET,EŞSİZ ŞEBNEM,PAÇAL NURETTİN,ÖZDEMİR FATMA İNCİ,ŞÜKÜR GÖZDE,YILDIRIM DENİZ | V. International Enzyme & Bioprocess Days | https://ebdays.org/ |
| 2023 | Molecular Characterization and Heterologous Production of Recombinant Iduronate 2-Sulfatase: A Promising Approach for Enzyme Replacement Therapy in Lysosomal Storage Disorders | International | KARATAŞ ERSİN, TÜLEK AHMET | 4nd Enzyme and Bioprocess Days (EBDAYS) Congress | https://www.ebdays.org/ |
| 2023 | Evaluation of multi-walled carbon nanotubes bearing aldehyde groups with different lengths for immobilization of Geobacillus kaustophilus L-asparaginase | International | ÖZDEMİR FATMA İNCİ, KARAASLAN BURCU, TÜLEK AHMET, YILDIRIM DENİZ | IV. International Enzyme & Bioprocess Days | https://www.ebdays.org/ |
| 2022 | A molecular dynamics study of a mutation on the allosteric site of formate dehydrogenase enzyme | International | SERVİLİ BURAK, RİNCH WARDAH AFZAL, TÜLEK AHMET, GÜNAY ELİF, YILDIRIM DENİZ, BİNAY BARIŞ, EŞSİZ ŞEBNEM | 3nd Enzyme and Bioprocess Days (EBDAYS) Congress | |
| 2021 | Pichia Pastoris Expression Systems for Producing Biocatalyst: Case Studies | International | TÜLEK AHMET, KARATAŞ ERSİN, BİNAY BARIŞ | 3nd International Eurasia Biochemical Approaches & Technologies (EBAT) Congress | |
| 2021 | Enhancing Chaetomium thermophilum formate dehydrogenases performance for CO2 reduction: Redesign and its immobilization on functionalized magnetic MWCNT-Ni composites | International | TÜLEK AHMET, GÜNAY ELİF, YILDIRIM DENİZ, SERVİLİ BURAK, EŞSİZ ŞEBNEM, BİNAY BARIŞ | 3nd Enzyme and Bioprocess Days (EBDAYS) Congress | |
| 2021 | Expression and Biochemical Characterization of Hypsibius dujardini Epoxide Hydrolase (HdEH) Enzyme in Pichia pastoris | International | ASLAN ELİF SİBEL, ONUR HAKAN, TÜLEK AHMET, BİNAY BARIŞ | 3nd International Eurasia Biochemical Approaches & 7.Technologies (EBAT) Congress | |
| 2020 | Heterologous expression of a novel Alanine dehydrogenase from Amycolatopsis sulphurea to obtain new Alanine derivatives | International | AKTAŞ FATİH, TÜLEK AHMET, BİNAY BARIŞ | II. International Enzyme & Bioprocess Days | |
| 2020 | Expression and Biochemical Characterization of Madurella mycetomatis Laccase Enzyme in Pichia pastoris | International | TÜLEK AHMET, ÜNLÜ AİŞE, KARATAŞ ERSİN, BİNAY BARIŞ | II. International Enzyme & Bioprocess Days | |
| 2020 | Immobilization Madurella mycetomatis laccase in metal-organic framework composite with mesoporous silica shells | International | TÜLEK AHMET, KARATAŞ ERSİN, YÜCEBİLGİÇ GÜZİDE, YILDIRIM DENİZ, BİNAY BARIŞ | II. International Enzyme & Bioprocess Days | |
| 2020 | Encapsulation of Sporothrix schenckii 1099-18 exo-polygalacturonase in Fe3O4-hollow silica Shell composites | International | KARATAŞ ERSİN, TÜLEK AHMET, TÜKEL SEYDE SEYHAN, YILDIRIM DENİZ, BİNAY BARIŞ | II. International Enzyme & Bioprocess Days | |
| 2020 | Characterization of a new Exo-polygalacturonase from Sporothrix schenckii 1099-18 in Pichia pastoris | International | KARATAŞ ERSİN, TÜLEK AHMET, ÇAKAR MEHMET MERVAN, TAMTÜRK FARUK, AKTAŞ FATİH, BİNAY BARIŞ | II. International Enzyme & Bioprocess Days | |
| 2019 | Cloning of a novel laccase gene from Madurella mycetomatis and expression in Pichia pastoris | International | TÜLEK AHMET, KARATAŞ ERSİN, BİNAY BARIŞ | 2th Eurasia Biochemical Approaches & Technologies (Ebat) Congress | |
| 2019 | Comparative Analysis of a New Microsomal Epoxide Hydrolase from Hypsibius dujardini | International | GAYIR VELİCAN ENGİN, TÜLEK AHMET, KARATAŞ ERSİN, BİNAY BARIŞ, ASLAN ELİF SİBEL | 2th Eurasia Biochemical Approaches & Technologies (Ebat) Congress | |
| 2019 | Heterologous Expression of a New Exo-Polygalacturonase from Sporothrix schenckii 1099-18 in Pichia pastoris | International | KARATAŞ ERSİN, TÜLEK AHMET, BİNAY BARIŞ | 2th Eurasia Biochemical Approaches & Technologies (Ebat) Congress | |
| 2017 | An investigation on effects of metals on formate dehydrogenase activity | International | BULUT HURİ, TÜLEK AHMET, BİNAY BARIŞ | Biotrans2017 13th International Symposium on Biocatalysis and Biotransformations | |
| 2017 | Asp188 is key residue in thermostability of Chaetomium thermophilum formate dehydrogenase | International | TÜLEK AHMET, YEŞİLÇİMEN AKBAŞ MELTEM, KARATAŞ ERSİN, BİNAY BARIŞ | Biotrans2017 13th International Symposium on Biocatalysis and Biotransformations | |
| 2017 | Biochemical Characterization of N-Termınally Truncated Ftsh Protease of Geobacillus kaustophilus | International | ÖZDEMİR FATMA İNCİ, RAMADHAN SALİM SAİM, TÜLEK AHMET | 7th Congress of European Microbiologists |
22222
| Year | Book Title | Chapter: | Contribution Level: |
|---|---|---|---|
| 2023 | Tarım Bilimlerinde Yenilikçi Multidisipliner Yaklaşımlar | Bitki Korumada Enzimolojik Yaklaşım: Lakkaz Enzimlerinin Biyoremediasyonda Kullanımı | Bölüm(ler) |
| 2021 | Olay yeri incelemede spesifik alanlar – I | Adli Genetikte Tek Nükleotid Polimorfizmi (SNP) İncelemeleri | Bölüm(ler) |
22222
| Year | Dissertation Title | Author: | Type: | Status: |
|---|
22222
| Academic Year | Course Title | Educational Level: |
|---|---|---|
| 2023-2024 | Kariyer Planlama | Associate |
| 2023-2024 | Tıbbi Biyoloji ve Genetik | Associate |
| 2023-2024 | Mikroskop Becerileri | Associate |
| 2023-2024 | Maya Biyoteknolojisi | Master |
| 2023-2024 | Gen İfadesinin Düzenlenmesi | Master |
| 2023-2024 | Protein Mühendisliği | Master |
| 2023-2024 | Sinyal Transdüksiyonu | Master |
| 2024-2025 | Protein Hedeflenmesi | Master |
22222
| Course Title | 1. Week: | 2. Week: | 3. Week: | 4. Week: | 5. Week: | 6. Week: | 7. Week: | 8. Week: | 9. Week: | 10. Week: | 11. Week: | 12. Week: | 13. Week: | 14. Week: |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mikroskop Becerileri | ||||||||||||||
| Tıbbi Biyoloji ve Genetik | ||||||||||||||
| Kariyer Planlama |
22222
| Project Title | Task: | Type: |
|---|---|---|
| Endüstriyel Biyoteknolojik Uygulamalar İçin Geobacillus kaustophilus L-Asparajinaz Tip II Enziminin İmmobilize Sistemler ile Performansının Artırılması | Araştırmacı | -Tübitak 1002 |
| Pankreas kanseri hücrelerinde içeri doğrultucu potasyum kanallarının rolü | Araştırmacı | Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi |
| Geobacillus kaustophilus ftsh geninin E. coli'de klonlanması, anlatımı ve biyokimyasal karakterizasyonu | Araştırmacı | Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi |
| Thermomicrobium roseum alanin dehidrogenez enziminin karakterizasyonu | Araştırmacı | Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi |
| Strepthothrix mycetomi'den izole edilen yeni bir difenol oksidaz enziminin E. coli'de ifade edilmesi ve biyokimyasal karakterizasyonu | Araştırmacı | Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi |
| Gaucher Hastalığının Enzim Replasman Tedavisi için Rekombinant İnsan β-glukoserebrosidaz enziminin Pichia pastoris protein ifade sisteminde yüksek verimde üretimi | Araştırmacı | TÜSEB |
| Enzim replasman tedavisinde kullanılabilecek yeni bir Iduronate 2-sulfatase enziminin Eschericia coli'de üretilmesi ve karakterizasyonu | Araştırmacı | Yükseköğretim Kurumları tarafından destekli bilimsel araştırma projesi |
| Geobacillus kaustophilus lipaz enziminin mutasyon ve immobilize sistemler ile performansının arttırılarak biyodizel üretiminde kullanılması | Yürütücü | -Tübitak 3501 |
| Sıcak Su Kaynaklarından Izole Edilen Termofilik Funguslardan Lakkaz Enzimlerinin Tanımlanması ve Boya Giderimi Potansiyellerinin Belirlenmesi | Araştırmacı | -Tübitak 1002 |
| Organofosfatlı Pestisit Kalıntılarının Zno/Rgo Nanopartikülüne Immobilize Lakkaz Ile Giderimine Yönelik Biyoteknolojik Yaklaşımlar | Araştırmacı | COST |
22222
| Patent Title | Inventors: | Category: | Scope: |
|---|
22222
| Year | Award Name | Institution: | Type: | Description: |
|---|---|---|---|---|
| 2021 | Highly-stable Madurella mycetomatis laccase immobilized in silica-coated ZIF-8 nanocomposites for environmentally friendly cotton bleaching process | Yayın Teşvik Ödülü | TÜBİTAK | |
| 2021 | Immobilization of Sporothrix schenckii 1099-18 exo-polygalacturonase in magnetic mesoporous silica yolk-shell spheres: Highly reusable biocatalysts for apple juice clarification | Yayın Teşvik Ödülü | TÜBİTAK | |
| 2023 | A new highly enantioselective stable epoxide hydrolase from Hypsibius dujardini: Expression in Pichia pastoris and immobilization in ZIF-8 for asymmetric hydrolysis of racemic styrene oxide | Yayın Teşvik Ödülü | TÜBİTAK | |
| 2023 | Sustainable production of formic acid from CO2 by a novel immobilized mutant formate dehydrogenase | Yayın Teşvik Ödülü | TÜBİTAK |
22222
| Institution | Status |
|---|---|
| COST | European Cooperation in Science and Technology CA21149 - Reducing acrylamide exposure of consumers by a cereals supply-chain approach targeting asparagine (ACRYRED) | Üye |
| COST | European Cooperation in Science and Technology CA18229 - NON-CONVENTIONAL YEASTS FOR THE PRODUCTION OF BIOPRODUCTS (YEAST4BIO) | Üye |
22222
| Date | Task | Unit: | Expiration Date: |
|---|